Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05505b Click here for additional data file.

Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants.

The pyranose spiroketal natural products pollenopyrroside A and shensongine A (also known as xylapyrroside A, ent-capparisine B) have been synthesized by stereoselective spirocyclizations of a common C1-functionalized glycal precursor. In conjunction with our previously reported syntheses of the corresponding furanose isomers, this provides a versatile family-level synthesis of the pyrrolomorph...

First total synthesis of concavine† †Electronic supplementary information (ESI) available. CCDC 1523963. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05627j Click here for additional data file. Click here for additional data file.

The synthesis of the unusual alkaloid concavine, isolated from Clitocybe concava (Basidiomycetae), has been accomplished. The synthetic route features regioand stereoselective manipulation of polycyclic imide intermediates via enolate substitution and Grignard addition, along with a key bridge-forming step involving a new method for sulfenylative radical cyclisation. The NMR data for synthetic ...

A family of cis-macrocyclic diphosphines: modular, stereoselective synthesis and application in catalytic CO2/ethylene coupling† †Electronic supplementary information (ESI) available: Full experimental, crystallographic and spectroscopic data. CCDC 1477899–1477902. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03614g Click here for additional data file. Click here for additional data file.

A family of cis-macrocyclic diphosphines: stereoselective synthesis and application in catalytic CO2/ethylene coupling Ioana Knopf,a Daniel Tofan,a Dirk Beetstra,b Abdulaziz Al-Nezari,b Khalid Al-Bahily,b and Christopher C. Cummins ∗,a a Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA b SABIC CRD, Fundamental Catalysis, Thuw...

Rhodium(i)-catalyzed stereoselective [4+2] cycloaddition of oxetanols with alkynes through C(sp3)–C(sp3) bond cleavage† †Electronic supplementary information (ESI) available. CCDC 1512439 and 1512440. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05246k Click here for additional data file. Click here for additional data file.

Remote stereoselective deconjugation of α,β-unsaturated esters by simple amidation reactions† †Electronic supplementary information (ESI) available. CCDC 1034974, 1034976–1034978. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc01118c Click here for additional data file. Click here for additional data file.